🍋
Limonene
LIM-oh-neen /ˈlɪməniːn/
Second most abundant terpene. Limonene provides uplifting effects and may help with anxiety and depression without psychotropic side effects.
Concentration
0.1-0.3% (can exceed 0.5%)
Strains Found
22+
Aroma Profile
Citrus, lemon, orange
Flavor Notes
Sweet citrus, tangy
Also Found In
Citrus fruits Rosemary Peppermint Juniper
Primary Effects
Anxiety reduction
Mood elevation
Stress relief
GABA enhancement
How It Works
- Modulates adenosine A2A receptors
- Reduces pro-inflammatory cytokines (TNF-α, IL-1β)
- Enhances GABA activity
- Does not strongly bind CB receptors
Clinical Evidence
2024 cross-over study: Vaporizing 1-5mg limonene with THC significantly reduced THC-induced anxiety without diminishing therapeutic effects. Limonene acts via adenosine A2A receptors and reduces pro-inflammatory cytokines.
Strains with Limonene
Explore 22 cannabis strains where Limonene is the dominant terpene
Want to learn more about cannabis terpenes?
Explore all 17 terpenes and discover which strains match your preferences
Browse All Terpenes